https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
‘It absolutely was only a issue of choosing up a guide on mobile biology and beginning to go through. I'd originate from a entire world of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Functioning at room temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport by an individual one-walled carbon nanotube. According to very low-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
We condition micro organism into varieties that deviate from their organic phenotype. Precisely, I'll demonstrate our capacity to shape Are living E. coli micro organism into novel styles such as rectangles, squares, triangles and circles.
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In 1993, being a youthful and eager associate professor at Delft University of Know-how, I'd at first centered the investigate efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. In just two many years, we had designed a tool in which just one wire of a phthalocyaninepolysiloxane polymer was linked involving two closely spaced metal nanoelectrodes.
Incredibly interesting, but that wasn’t genuinely wherever my fascination lay. I planned to pioneer and I experienced the sensation which was no more doable, since the most appealing fundamental insights had by now been uncovered. But my area experienced made many thrilling new applications to evaluate personal molecules. I made a decision which i wanted to use this to biology, to have a look at it from a Bodily standpoint.’
Screening pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Mother nature Physics many thanks the anonymous reviewers for his or her contribution for the peer evaluation of the perform.
2005, discovery of the mechanism of DNA uncoiling by topoisomerase ceesdekker enzymes; discovery of extensive-variety conformational variations in Mre11/DNA fix complexes; and to start with force measurements over a DNA molecule in a nanopore
2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes