A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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2009, discovery of a whole new phenotype for bacteria in narrow nanofluidic slits; and very first detection of community protein buildings alongside DNA working with good-point out nanopores
Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination functionality.
Within the very same time, the group of Paul McEuen, who was then centered with the University of California, Berkeley, confirmed equivalent final results on ropes of bundled nanotubes. Dependant upon the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified utilizing scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of personal DNA molecules recaptured around one thousand instances within a sound state nanopore
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Our analysis ranges from your biophysics of DNA to synthetic cells and past. Make sure you have a look below at the spectrum of our current projects.
‘Initially we looked at Organic units using a Bodily perspective and acted on the basis on the applications we knew. It took a couple of years in advance of we started Functioning far more on the massive Organic issues. I then started to get in touch with it nanobiology, a expression that didn't exist at some time.
2011, to start with in vitro measurements of transportation throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the initial biosensors created from a carbon nanotube; resolved the composition and system of DNA repair service proteins; and discovery of a different strategy for fabricating stable-condition nanopores for DNA translocation
Dekker commenced his analysis on single carbon nanotubes in 1993 when he build a whole new line of study to check electrical transport through one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was reached inside a collaboration with the group of Nobel laureate Richard Smalley. STM and nanolithography techniques ended up used to reveal that these nanotubes are quantum wires at The only-molecule amount, with fantastic physical Houses.
Tests pseudotopological and nontopological designs for SMC-driven DNA loop extrusion versus roadblock-traversal experiments
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Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, in addition to a 3D rendering in the movement in the DNA rod is exhibited.